SrasV1, Main, Exploration, bibRecord, 001F23

Avian coronavirus Spike Glycoprotein Ectodomain Shows a Low Codon Adaptation to Gallus gallus with Virus-Exclusive Codons in Strategic Amino Acids Positions

Identifieur interne : 001F23 ( Main/Exploration ); précédent : 001F22; suivant : 001F24

Avian coronavirus Spike Glycoprotein Ectodomain Shows a Low Codon Adaptation to Gallus gallus with Virus-Exclusive Codons in Strategic Amino Acids Positions

Auteurs : Paulo E. Brandão [Brésil]

Source :

Journal of Molecular Evolution [ 0022-2844 ] ; 2012-08-01.

RBID : ISTEX:186B894B921427384F72B8257822D9B1751472CF

Descripteurs français

KwdFr :
- Animaux, Codon, Coronavirus (génétique), Dérive génétique, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Modèles génétiques, Phylogénie, Poulets (virologie), Protéines de l'enveloppe virale (génétique), Sélection génétique, Séquence d'acides aminés.
MESH :
- génétique : Coronavirus, Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- virologie : Poulets.
- Animaux, Codon, Dérive génétique, Glycoprotéine de spicule des coronavirus, Modèles génétiques, Phylogénie, Sélection génétique, Séquence d'acides aminés.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Avian coronavirus, Chickens (virology), Co-evolution, Codon, Codon usage bias, Coronavirus (genetics), Gallus gallus, Genetic Drift, Membrane Glycoproteins (genetics), Models, Genetic, Phylogeny, Selection, Genetic, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics).
MESH :
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical : Codon, Spike Glycoprotein, Coronavirus.
- genetics : Coronavirus.
- virology : Chickens.
- Amino Acid Sequence, Animals, Genetic Drift, Models, Genetic, Phylogeny, Selection, Genetic.

Abstract

Abstract: This is a study on the Avian coronavirus IBV and chicken host-relationship from the codon usage point of view based on fifty-nine non-redundant IBV S1 sequences (nt 1–507) from strains detected worldwide and chicken tissue-specific protein genes sequences from IBV-replicating sites. The effective number of codons (ENC) values ranged from 36 to 47.8, indicating a high-to-moderate codon usage bias. The highest IBV codon adaptation index (CAI) value was 0.7, indicating a distant virus versus host synonymous codons usage. The ENC × GC3 % curve indicates that both mutational pressure and natural selection are the driving forces on codon usage pattern in S1. The low CAI values agree with a low S protein expression and considering that S protein is a determinant for attachment and neutralization, this could be a further mechanism besides mRNA transcription attenuation for a low expression of this protein leading to an immune camouflage.

Url:

https://api.istex.fr/ark:/67375/VQC-WBXK5C95-Z/fulltext.pdf

DOI: 10.1007/s00239-012-9515-2

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: This is a study on the Avian coronavirus IBV and chicken host-relationship from the codon usage point of view based on fifty-nine non-redundant IBV S1 sequences (nt 1–507) from strains detected worldwide and chicken tissue-specific protein genes sequences from IBV-replicating sites. The effective number of codons (ENC) values ranged from 36 to 47.8, indicating a high-to-moderate codon usage bias. The highest IBV codon adaptation index (CAI) value was 0.7, indicating a distant virus versus host synonymous codons usage. The ENC × GC3 % curve indicates that both mutational pressure and natural selection are the driving forces on codon usage pattern in S1. The low CAI values agree with a low S protein expression and considering that S protein is a determinant for attachment and neutralization, this could be a further mechanism besides mRNA transcription attenuation for a low expression of this protein leading to an immune camouflage.</div>
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Avian coronavirus Spike Glycoprotein Ectodomain Shows a Low Codon Adaptation to Gallus gallus with Virus-Exclusive Codons in Strategic Amino Acids Positions

Avian coronavirus Spike Glycoprotein Ectodomain Shows a Low Codon Adaptation to Gallus gallus with Virus-Exclusive Codons in Strategic Amino Acids Positions

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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